在过去的十年中，图上的信号处理已成为一个非常活跃的研究领域。具体而言，使用从图形上构建的框架（例如图上的小波）在统计或深度学习中的应用数量显着增加。我们特别考虑通过数据驱动的小波紧密框架方法在图表上进行信号的情况。这种自适应方法基于使用Stein的无偏风险估计校准的阈值，该阈值适合于紧密框架表示。我们可以使用Chebyshev-Jackson多项式近似值将其扩展到大图，从而可以快速计算小波系数，而无需计算laplacian特征性组成。但是，紧密框架的过度本质将白噪声转化为相关的噪声。结果，转换噪声的协方差出现在确定的差异项中，因此需要计算和存储框架，从而导致大图的不切实际计算。为了估计这种协方差，我们基于零均值和单位方差随机变量的快速转换制定和分析蒙特卡洛策略。这种新的数据驱动的denoisisy方法可以在差异隐私中发现自然应用。从真实和模拟数据的大小变化图上进行了全面的性能分析。

This paper tackles the challenging problem of automating code updates to fix deprecated API usages of open source libraries by analyzing their release notes. Our system employs a three-tier architecture: first, a web crawler service retrieves deprecation documentation from the web; then a specially built parser processes those text documents into tree-structured representations; finally, a client IDE plugin locates and fixes identified deprecated usages of libraries in a given codebase. The focus of this paper in particular is the parsing component. We introduce a novel transition-based parser in two variants: based on a classical feature engineered classifier and a neural tree encoder. To confirm the effectiveness of our method, we gathered and labeled a set of 426 API deprecations from 7 well-known Python data science libraries, and demonstrated our approach decisively outperforms a non-trivial neural machine translation baseline.

Generalisation to unseen contexts remains a challenge for embodied navigation agents. In the context of semantic audio-visual navigation (SAVi) tasks, the notion of generalisation should include both generalising to unseen indoor visual scenes as well as generalising to unheard sounding objects. However, previous SAVi task definitions do not include evaluation conditions on truly novel sounding objects, resorting instead to evaluating agents on unheard sound clips of known objects; meanwhile, previous SAVi methods do not include explicit mechanisms for incorporating domain knowledge about object and region semantics. These weaknesses limit the development and assessment of models' abilities to generalise their learned experience. In this work, we introduce the use of knowledge-driven scene priors in the semantic audio-visual embodied navigation task: we combine semantic information from our novel knowledge graph that encodes object-region relations, spatial knowledge from dual Graph Encoder Networks, and background knowledge from a series of pre-training tasks -- all within a reinforcement learning framework for audio-visual navigation. We also define a new audio-visual navigation sub-task, where agents are evaluated on novel sounding objects, as opposed to unheard clips of known objects. We show improvements over strong baselines in generalisation to unseen regions and novel sounding objects, within the Habitat-Matterport3D simulation environment, under the SoundSpaces task.

Current language models are considered to have sub-human capabilities at natural language tasks like question-answering or writing code. However, language models are not trained to perform well at these tasks, they are trained to accurately predict the next token given previous tokes in tokenized text. It is not clear whether language models are better or worse than humans at next token prediction. To try to answer this question, we performed two distinct experiments to directly compare humans and language models on this front: one measuring top-1 accuracy and the other measuring perplexity. In both experiments, we find humans to be consistently \emph{worse} than even relatively small language models like GPT3-Ada at next-token prediction.

The estimation of the generalization error of classifiers often relies on a validation set. Such a set is hardly available in few-shot learning scenarios, a highly disregarded shortcoming in the field. In these scenarios, it is common to rely on features extracted from pre-trained neural networks combined with distance-based classifiers such as nearest class mean. In this work, we introduce a Gaussian model of the feature distribution. By estimating the parameters of this model, we are able to predict the generalization error on new classification tasks with few samples. We observe that accurate distance estimates between class-conditional densities are the key to accurate estimates of the generalization performance. Therefore, we propose an unbiased estimator for these distances and integrate it in our numerical analysis. We show that our approach outperforms alternatives such as the leave-one-out cross-validation strategy in few-shot settings.

Generative Adversarial Networks (GANs) were introduced by Goodfellow in 2014, and since then have become popular for constructing generative artificial intelligence models. However, the drawbacks of such networks are numerous, like their longer training times, their sensitivity to hyperparameter tuning, several types of loss and optimization functions and other difficulties like mode collapse. Current applications of GANs include generating photo-realistic human faces, animals and objects. However, I wanted to explore the artistic ability of GANs in more detail, by using existing models and learning from them. This dissertation covers the basics of neural networks and works its way up to the particular aspects of GANs, together with experimentation and modification of existing available models, from least complex to most. The intention is to see if state of the art GANs (specifically StyleGAN2) can generate album art covers and if it is possible to tailor them by genre. This was attempted by first familiarizing myself with 3 existing GANs architectures, including the state of the art StyleGAN2. The StyleGAN2 code was used to train a model with a dataset containing 80K album cover images, then used to style images by picking curated images and mixing their styles.

Graph learning problems are typically approached by focusing on learning the topology of a single graph when signals from all nodes are available. However, many contemporary setups involve multiple related networks and, moreover, it is often the case that only a subset of nodes is observed while the rest remain hidden. Motivated by this, we propose a joint graph learning method that takes into account the presence of hidden (latent) variables. Intuitively, the presence of the hidden nodes renders the inference task ill-posed and challenging to solve, so we overcome this detrimental influence by harnessing the similarity of the estimated graphs. To that end, we assume that the observed signals are drawn from a Gaussian Markov random field with latent variables and we carefully model the graph similarity among hidden (latent) nodes. Then, we exploit the structure resulting from the previous considerations to propose a convex optimization problem that solves the joint graph learning task by providing a regularized maximum likelihood estimator. Finally, we compare the proposed algorithm with different baselines and evaluate its performance over synthetic and real-world graphs.

The use of needles to access sites within organs is fundamental to many interventional medical procedures both for diagnosis and treatment. Safe and accurate navigation of a needle through living tissue to an intra-tissue target is currently often challenging or infeasible due to the presence of anatomical obstacles in the tissue, high levels of uncertainty, and natural tissue motion (e.g., due to breathing). Medical robots capable of automating needle-based procedures in vivo have the potential to overcome these challenges and enable an enhanced level of patient care and safety. In this paper, we show the first medical robot that autonomously navigates a needle inside living tissue around anatomical obstacles to an intra-tissue target. Our system leverages an aiming device and a laser-patterned highly flexible steerable needle, a type of needle capable of maneuvering along curvilinear trajectories to avoid obstacles. The autonomous robot accounts for anatomical obstacles and uncertainty in living tissue/needle interaction with replanning and control and accounts for respiratory motion by defining safe insertion time windows during the breathing cycle. We apply the system to lung biopsy, which is critical in the diagnosis of lung cancer, the leading cause of cancer-related death in the United States. We demonstrate successful performance of our system in multiple in vivo porcine studies and also demonstrate that our approach leveraging autonomous needle steering outperforms a standard manual clinical technique for lung nodule access.

To apply federated learning to drug discovery we developed a novel platform in the context of European Innovative Medicines Initiative (IMI) project MELLODDY (grant n{\deg}831472), which was comprised of 10 pharmaceutical companies, academic research labs, large industrial companies and startups. The MELLODDY platform was the first industry-scale platform to enable the creation of a global federated model for drug discovery without sharing the confidential data sets of the individual partners. The federated model was trained on the platform by aggregating the gradients of all contributing partners in a cryptographic, secure way following each training iteration. The platform was deployed on an Amazon Web Services (AWS) multi-account architecture running Kubernetes clusters in private subnets. Organisationally, the roles of the different partners were codified as different rights and permissions on the platform and administrated in a decentralized way. The MELLODDY platform generated new scientific discoveries which are described in a companion paper.

语音活动检测（VAD）旨在检测音频信号上的语音段，这对于许多今天的基于语音的应用程序来说是必要的第一步。当前的最新方法着重于训练直接包含声学中包含的神经网络，例如MEL Filter Basks（MFBS）。因此，此类方法需要一个额外的归一化步骤，以适应影响声学的新领域，这可能仅仅是由于说话者，麦克风或环境的变化所致。此外，这个归一化步骤通常是一种具有一定局限性的基本方法，例如高度容易受到新域可用的数据量。在这里，我们利用了众包共同的声音（CV）语料库，以表明基于自我监督学习（SSL）的表示形式可以很好地适应不同的领域，因为它们是通过跨多个领域的语音表达来计算的。 SSL表示也比基于手工制作的表示（MFB）和现成的VAD的系统获得更好的结果，并在跨域设置方面有了显着改善。